| 20/10/2017 | ||
| Royal Excel Mo… | 20:30 | Standard Liège |
| 21/10/2017 | ||
| Lokeren | 18:00 | Sporting Charleroi |
| Sint-Truiden | 20:00 | KV Oostende |
| AS Eupen | 20:00 | Mechelen |
| Kortrijk | 20:30 | Gent |
| 22/10/2017 | ||
| Club Brugge | 14:30 | Antwerp |
| Anderlecht | 18:00 | Genk |
| Zulte-Waregem | 20:00 | Waasland-Beveren |
| 24/10/2017 | ||
| Mechelen | 20:30 | Lokeren |
| KV Oostende | 20:30 | Sporting Charleroi |
| Gent | 20:30 | AS Eupen |
| 25/10/2017 | ||
| Waasland-Beveren | 20:30 | Kortrijk |
| Genk | 20:30 | Club Brugge |
| Anderlecht | 20:30 | Zulte-Waregem |
| 26/10/2017 | ||
| Sint-Truiden | 20:30 | Royal Excel Mo… |
| Antwerp | 20:30 | Standard Liège |
| 27/10/2017 | ||
| Sporting Charleroi | 20:30 | Gent |
